Testing of nebulizers for delivering magnesium sulfate to pediatric asthma patients in the emergency department.
نویسندگان
چکیده
BACKGROUND As the use of intravenous magnesium sulfate (MgSO(4)) for the treatment of refractory asthma is becoming more common, the incidence of MgSO(4)-related systemic hypotension is also rising. One option is to deliver MgSO(4) via aerosol, but compared to most inhaled medications, which are active in the microgram dose range, the MgSO(4) dose requirement is in the milligram range. This, along with inefficient aerosol delivery systems, may be the reason that some studies have found lack of efficacy with aerosol MgSO(4). In preparation for a multicenter study of inhaled MgSO(4) in asthmatic children 2-17 years old, we conducted an in vitro study to choose the best MgSO(4) nebulizer system that would be effective over the entire age range. METHODS We tested the Pari LC Star jet nebulizer, Omron MicroAir vibrating-mesh nebulizer, and the Aeroneb Go vibrating-mesh nebulizer with the Idehaler valve-less holding chamber. Aerosol delivery was via face mask. RESULTS The Pari LC Star had an appropriate particle size distribution but a very slow aerosol output rate. The Omron MicroAir had an even slower output rate and a larger particle size distribution, which would be inappropriate for smaller children. In vitro lung deposition with the Aeroneb Go with Idehaler was 16.0 ± 0.4 mg/min in older children and approximately a fifth of that in toddlers. CONCLUSIONS The Aeroneb Go with Idehaler was chosen for the multicenter clinical study.
منابع مشابه
Intravenous magnesium therapy for moderate to severe pediatric asthma: results of a randomized, placebo-controlled trial.
OBJECTIVE To evaluate the efficacy of intravenous magnesium (IVMg) therapy for moderate to severe asthma exacerbations in pediatric patients. DESIGN Randomized, double-blind, placebo-controlled, clinical trial. SETTING Urban pediatric emergency department. PARTICIPANTS Thirty-one patients aged 6 to 18 years who were being treated for an acute asthma exacerbation with peak expiratory flow ...
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متن کاملMagnesium sulfate for treating exacerbations of acute asthma in the emergency department.
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متن کاملHigher-dose intravenous magnesium therapy for children with moderate to severe acute asthma.
OBJECTIVE To evaluate the efficacy of a 40-mg/kg dose of intravenous magnesium sulfate for moderate to severe asthma exacerbations in pediatric patients. STUDY DESIGN Double-blind placebo-controlled trial. SETTING Two urban tertiary care pediatric emergency departments. SUBJECTS Thirty patients, aged 6 to 17.9 years, being treated for an acute asthma exacerbation. INTERVENTION Eligible ...
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ورودعنوان ژورنال:
- Respiratory care
دوره 56 3 شماره
صفحات -
تاریخ انتشار 2011